2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W055870
    Hydroxy-PEG1-(CH2)2-Boc 671802-00-9
    Hydroxy-PEG1-(CH2)2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG1-(CH2)2-Boc
  • HY-141186
    TCO-OH 85081-69-2 ≥98.0%
    TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-OH
  • HY-23166
    Bis-PEG1-acid 5961-83-1 99.90%
    Bis-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bis-PEG1-acid
  • HY-140661
    Azide-PEG-amine (MW 2000)
    Azide-PEG-amine (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG-amine (MW 2000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG-amine (MW 2000)
  • HY-130142A
    Biotinyl-NH-PEG3-C3-amido-C3-COOH 1202761-21-4 99.91%
    Biotinyl-NH-PEG3-C3-amido-C3-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotinyl-NH-PEG3-C3-amido-C3-COOH
  • HY-W008568
    Fmoc-amino-PEG3-CH2COOH 139338-72-0 99.60%
    Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-amino-PEG3-CH2COOH
  • HY-140232
    Boc-NH-PEG7-NH2 206265-98-7
    Boc-NH-PEG7-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG7-NH2
  • HY-W004896
    Boc-NH-PEG2 139115-91-6 99.78%
    Boc-NH-PEG2 (PROTAC Linker 11) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG2
  • HY-135821
    Fmoc-NH-PEG12-CH2CH2COOH 1952360-91-6 ≥98.0%
    Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG12-CH2CH2COOH
  • HY-W050087
    Octaethylene glycol 5117-19-1 99.97%
    Octaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Octaethylene glycol
  • HY-140648
    Amine-PEG-amine (MW 5000)
    Amine-PEG-amine (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amine-PEG-amine (MW 5000)
  • HY-130525
    Iodo-PEG3-N3 936917-36-1
    Iodo-PEG3-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Iodo-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Iodo-PEG3-N3
  • HY-130825
    Bis-PEG13-NHS ester 2221949-00-2 ≥98.0%
    Bis-PEG13-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG13-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG13-NHS ester
  • HY-112496
    Cl-C6-PEG4-O-CH2COOH 1799506-30-1 ≥98.0%
    Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PEG-based PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).
    Cl-C6-PEG4-O-CH2COOH
  • HY-141230
    Hexaethylene glycol 2615-15-8 99.87%
    Hexaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hexaethylene glycol
  • HY-140902A
    Biotin-PEG3-C3-NH2 183896-00-6
    Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs.
    Biotin-PEG3-C3-NH2
  • HY-42637
    N3-PEG3-CH2COOH 172531-37-2 99.75%
    N3-PEG3-CH2COOH (PROTAC Linker 14) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. N3-PEG3-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-PEG3-CH2COOH
  • HY-W008429
    m-PEG2-Amine 31576-51-9 99.85%
    m-PEG2-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG2-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG2-Amine
  • HY-140900
    Biotin-PEG11-amine 1418022-42-0 99.85%
    Biotin-PEG11-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG11-amine
  • HY-130148
    m-PEG8-Br 1056881-04-9 ≥98.0%
    m-PEG8-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG8-Br
PROTAC Linkers Isoform Comparison

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